OpossumBase is a comprehensive resource for genetic and genomic data from opossums and other American marsupial species used as model organisms in genetically related research. Intended primarily as a source and repository for expressed sequence data (ESTs) from the gray, short-tailed opossum, Monodelphis domestica, OpossumBase also provides links to genomics tools, other genomic databases, genetic maps, cytologic data, biologic resources, and other websites for this and other marsupial species. It is hoped that OpossumBase will establish a useful forum for news items and the exchange of information concerning research problems, animal husbandry issues, and potential collaborative opportunities within and beyond the marsupial research community.
As the only full-draft sequence of a marsupial genome, the M. domestica genome assembly, MonDom5 is the most widely used non-eutherian mammal genome for studying the evolution and functional attributes of coding and non-coding genomic elements among mammals and across vertebrates generally; it is also crucially important as a template for assembling genome structures and gene models for other marsupial species. Current annotation of MonDom5 is based almost exclusively on automated predictive algorithms with virtually no assistance from expressed sequence data. OpossumBase furnishes novel information on transcripts from a broad variety of tissues, organs, and life stages that will facilitate refinement of MonDom5 annotation by determining the genomic coordinates of expressed sequences, evaluating and improving existing gene models, and discovering previously unknown genes.
The form and content of this website is a work in progress and we welcome helpful suggestions from the research community for its improvement and expansion.